Targeting protein stability with a small molecule.

Michael A Lampson; Tarun M Kapoor

doi:10.1016/j.cell.2006.08.023

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Targeting protein stability with a small molecule.

Michael A Lampson·Tarun M Kapoor

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Abstract

Both genetic approaches and small-molecule inhibitors can be used to perturb protein function. Banaszynski et al. (2006) now describe a strategy to regulate the stability of a target protein, in which specificity is provided by a genetically encoded tag and temporal control is imparted by a small molecule.

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Animals Gene Expression Regulation Ligands Luminescent Proteins Mice Mutation Proteasome Endopeptidase Complex Protein Binding Protein Structure, Tertiary Recombinant Fusion Proteins Sirolimus Tacrolimus Binding Protein 1A Tacrolimus Binding Proteins Comment Journal Article

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Michael A Lampson, Tarun M Kapoor. 2006-09-08. Targeting protein stability with a small molecule.. https://doi.org/10.1016/j.cell.2006.08.023

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