Combined decrease of defined B and T cell subsets in a group of common variable immunodeficiency patients.

Daniele Moratto; Anna Virginia Gulino; Stefania Fontana; Luigi Mori; Silvia Pirovano; Annarosa Soresina; Antonella Meini; Luisa Imberti; Luigi Daniele Notarangelo; Alessandro Plebani; Raffaele Badolato

doi:10.1016/j.clim.2006.07.003

PubMed · 16962827

Combined decrease of defined B and T cell subsets in a group of common variable immunodeficiency patients.

Daniele Moratto·Anna Virginia Gulino·Stefania Fontana·Luigi Mori·Silvia Pirovano·Annarosa Soresina·Antonella Meini·Luisa Imberti·Luigi Daniele Notarangelo·Alessandro Plebani·Raffaele Badolato

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Abstract

Common variable immunodeficiency disease (CVID) is a primary immune disorder affecting B cells and characterized by hypogammaglobulinemia and recurrent infections. To elucidate the clinical and immunological heterogeneity of this condition, we have studied B and T cell subsets in 25 CVID patients. In eleven of them, we observed a remarkable relative expansion of a B cell subpopulation (CD19(hi)/CD21(lo) cells) characterized by the absence of CD23 and the reduced expression of the chemokine receptors CXCR5 and CCR7. Our analyses demonstrated in these patients that the expansion of CD19(hi)/CD21(lo) cells correlates with a selective decrease of circulating naïve and CD21(hi) memory B lymphocytes. The same group of patients displayed a simultaneous severe reduction of naïve CD4+ T cells associated with decreased levels of T cell receptor excision circles. These observations suggest that a combined defect in generation of B and T subpopulations may account for the abnormal immunophenotype characterizing this subgroup of CVID patients.

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Daniele Moratto, Anna Virginia Gulino, Stefania Fontana, Luigi Mori, Silvia Pirovano, Annarosa Soresina, Antonella Meini, Luisa Imberti, Luigi Daniele Notarangelo, Alessandro Plebani, Raffaele Badolato. 2006-09-07. Combined decrease of defined B and T cell subsets in a group of common variable immunodeficiency patients.. https://doi.org/10.1016/j.clim.2006.07.003

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