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PubMed · 16989532

Alkaloids from Gelsemium elegans.

You-Kai Xu·Sheng-Ping Yang·Shang-Gao Liao·Hua Zhang·Li-Ping Lin·Jian Ding·Jian-Min Yue
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Abstract

Three new alkaloids, gelsebanine (1), 14alpha-hydroxyelegansamine (2), and 14alpha-hydroxygelsamydine (3), and a new extraction artifact , gelsebamine (4), together with 12 known alkaloids, were isolated from the stems and leaves of Gelsemium elegans. The structures of 1-4 were determined by spectroscopic methods, especially 2D NMR techniques. Compounds 1-4 were evaluated for cytotoxic activity against four tumor cell lines, and gelsebamine (4) selectively inhibited the A-549 human lung adenocarcinoma cell line.

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Antineoplastic Agents, PhytogenicDrug Screening Assays, AntitumorDrugs, Chinese HerbalGelsemiumHumansIndole AlkaloidsMolecular StructureNuclear Magnetic Resonance, BiomolecularPlant LeavesPlant StemsPlants, MedicinalJournal ArticleResearch Support, Non-U.S. Gov't

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You-Kai Xu, Sheng-Ping Yang, Shang-Gao Liao, Hua Zhang, Li-Ping Lin, Jian Ding, Jian-Min Yue. 2006. Alkaloids from Gelsemium elegans.. https://doi.org/10.1021/np060156y

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