Postchallenge glucose rises with increasing age even when glucose tolerance is normal.

M K Rhee; D C Ziemer; P Kolm; L S Phillips

doi:10.1111/j.1464-5491.2006.01956.x

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PubMed · 17054591

Postchallenge glucose rises with increasing age even when glucose tolerance is normal.

M K Rhee·D C Ziemer·P Kolm·L S Phillips

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Abstract

AIMS: Ageing increases the likelihood of developing diabetes, with associated cardiovascular disease. In a cross-sectional study, we sought to determine whether age is associated with an increase in glucose concentrations 1 h after an oral glucose challenge (1-h OGTT), even when glucose tolerance is normal (NGT). METHODS: Among subjects in the NHANES II database, 2591 subjects with NGT and documented 1-h OGTT glucose concentrations were studied. The relationship between age and 1-h OGTT glucose concentrations was assessed in a multivariable linear regression analysis. RESULTS: In a multivariable linear regression analysis, each 10-year increase in age conferred an additional 0.20 mmol/l increase in the 1-h OGTT glucose (P < 0.0001). Moreover, an interaction between age and gender was found such that 1-h OGTT glucose concentrations rose more rapidly with increasing age in men than in women. The impact of age on 1-h OGTT glucose was independent of both fasting and 2-h OGTT glucose concentrations. CONCLUSIONS: One-hour OGTT glucose concentrations rise significantly with age even in subjects with NGT. Further investigation is warranted to explore the pathophysiological significance of such age-related impairment of glucose handling, which might increase the risk of cardiovascular disease even when patients do not meet criteria for the diagnosis of diabetes or prediabetes.

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Adolescent Adult Age Factors Aged Blood Glucose Child Child, Preschool Cross-Sectional Studies Diabetes Mellitus Female Glucose Intolerance Humans Infant Male Middle Aged Risk Factors Time Factors Journal Article Research Support, N.I.H., Extramural

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M K Rhee, D C Ziemer, P Kolm, L S Phillips. 2006. Postchallenge glucose rises with increasing age even when glucose tolerance is normal.. https://doi.org/10.1111/j.1464-5491.2006.01956.x

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