The complex route to MHC class I-peptide complexes.

Tim Elliott; Jacques Neefjes

doi:10.1016/j.cell.2006.10.001

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The complex route to MHC class I-peptide complexes.

Tim Elliott·Jacques Neefjes

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Abstract

The loading of peptides into the groove of MHC class I molecules prior to antigen presentation is a complex process. In this issue of Cell, Park et al. (2006) show that peptide loading gets a helping hand from a resident ER enzyme called protein disulfide isomerase, a chaperone that has oxidoreductase activity.

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Antigen Presentation Cytomegalovirus Infections Histocompatibility Antigens Class I Humans Oxidation-Reduction Peptides Proteasome Endopeptidase Complex Protein Disulfide-Isomerases Sulfhydryl Compounds Comment Journal Article

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Tim Elliott, Jacques Neefjes. 2006-10-20. The complex route to MHC class I-peptide complexes.. https://doi.org/10.1016/j.cell.2006.10.001

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