Tissue engineering for tendon repair.

Pierre-Olivier Bagnaninchi; Ying Yang; Alicia J El Haj; Nicola Maffulli

doi:10.1136/bjsm.2006.030643

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PubMed · 17062654

Tissue engineering for tendon repair.

Pierre-Olivier Bagnaninchi·Ying Yang·Alicia J El Haj·Nicola Maffulli

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Abstract

Tissue engineering aims to induce tissue self-regeneration in vivo or to produce a functional tissue replacement in vitro to be then implanted in the body. To produce a viable and functional tendon, a uniaxially orientated collagen type I matrix has to be generated. Biochemical and physical factors can potentially alter both the production and the organisation of this matrix, and their combination in a dose- and time-dependent manner is probably the key to in vitro engineered tendons. This review discusses the role of these different factors affecting tenocyte growth in a three-dimensional environment in vivo and in vitro, and underlines the future challenge of tendon tissue engineering.

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Biocompatible Materials Female Humans Male Prostheses and Implants Plastic Surgery Procedures Regeneration Risk Factors Sensitivity and Specificity Stress, Mechanical Tendinopathy Tendon Injuries Tendons Tensile Strength Tissue Engineering Journal Article Research Support, Non-U.S. Gov't Review

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Pierre-Olivier Bagnaninchi, Ying Yang, Alicia J El Haj, Nicola Maffulli. 2006-10-24. Tissue engineering for tendon repair.. https://doi.org/10.1136/bjsm.2006.030643

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