Increased levels of air pollution and a decrease in the human and mouse male-to-female ratio in São Paulo, Brazil.

Ana Julia F C Lichtenfels; Joabner B Gomes; Patrícia C Pieri; Simone G El Khouri Miraglia; Jorge Hallak; Paulo H N Saldiva

doi:10.1016/j.fertnstert.2006.06.023

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Increased levels of air pollution and a decrease in the human and mouse male-to-female ratio in São Paulo, Brazil.

Ana Julia F C Lichtenfels·Joabner B Gomes·Patrícia C Pieri·Simone G El Khouri Miraglia·Jorge Hallak·Paulo H N Saldiva

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Abstract

A significant negative association (R(2) = 0.7642; P=.013) between particulate matter and secondary sex ratio was found when evaluating people in the city of São Paulo, Brazil. An animal model with male mice raised in nonfiltered open-top chambers showed a significant reduction in the secondary sex ratio (P=.041), suggesting that ambient air pollution may interfere with sex distribution by altering the X:Y sperm proportion in pollution-exposed males.

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Air Pollution Animals Brazil Cities Female Humans Male Mice Models, Animal Sex Ratio Statistics as Topic Journal Article Research Support, Non-U.S. Gov't

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Ana Julia F C Lichtenfels, Joabner B Gomes, Patrícia C Pieri, Simone G El Khouri Miraglia, Jorge Hallak, Paulo H N Saldiva. 2006-11-02. Increased levels of air pollution and a decrease in the human and mouse male-to-female ratio in São Paulo, Brazil.. https://doi.org/10.1016/j.fertnstert.2006.06.023

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