Iron deficiency and brain development.

Betsy Lozoff; Michael K Georgieff

doi:10.1016/j.spen.2006.08.004

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Iron deficiency and brain development.

Betsy Lozoff·Michael K Georgieff

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Abstract

Iron deficiency (ID) is common in pregnant women and infants worldwide. Rodent models show that ID during gestation/lactation alters neurometabolism, neurotransmitters, myelination, and gene/protein profiles before and after iron repletion at weaning. Human infants with iron deficiency anemia test lower in cognitive, motor, social-emotional, and neurophysiologic development than comparison group infants. Iron therapy does not consistently improve developmental outcome, with long-term differences observed. Poorer outcome has also been shown in human and monkey infants with fetal/neonatal ID. Recent randomized trials of infant iron supplementation show benefits, indicating that adverse effects can be prevented and/or reversed with iron earlier in development or before ID becomes severe or chronic. This body of research emphasizes the importance of protecting the developing brain from ID.

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Animals Brain Child, Preschool Female Fetus Humans Infant Infant, Newborn Iron Deficiencies Mice Pregnancy Rats Journal Article Research Support, N.I.H., Extramural Review

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Betsy Lozoff, Michael K Georgieff. 2006. Iron deficiency and brain development.. https://doi.org/10.1016/j.spen.2006.08.004

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