A new function for p53 ubiquitination.

Yuko Hirano; Ze'ev Ronai

doi:10.1016/j.cell.2006.11.003

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A new function for p53 ubiquitination.

Yuko Hirano·Ze'ev Ronai

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Abstract

The amount of p53 protein in a cell is normally limited by ubiquitin-dependent degradation. In this issue of Cell, Le Cam et al. (2006) reveal that p53 ubiquitination contributes to transcriptional activation rather than protein stability. These results may provide insight into how p53 can modulate diverse cellular processes such as growth arrest and apoptosis.

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Cell Cycle Proteins Histone Acetyltransferases Humans Lysine Proto-Oncogene Proteins c-mdm2 Repressor Proteins Transcription Factors Tumor Suppressor Protein p53 Ubiquitin-Protein Ligases p300-CBP Transcription Factors p300-CBP-Associated Factor Journal Article Comment

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Yuko Hirano, Ze'ev Ronai. 2006-11-17. A new function for p53 ubiquitination.. https://doi.org/10.1016/j.cell.2006.11.003

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