Dissecting the coupling between the voltage sensor and pore domains.

Benoit Roux

doi:10.1016/j.neuron.2006.11.002

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Dissecting the coupling between the voltage sensor and pore domains.

Benoit Roux

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Abstract

The gating mechanism of K(v) channels is not known. In this issue of Neuron, Soler-Llavina et al. present fascinating results that support the concept of relatively independent voltage-sensing modules. However, they also find that its interactions with the pore domain are rather complex, with specific S4-S5 intersubunit contacts underlying the concerted transition leading to the channel opening.

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Animals Cell Membrane Crystallography, X-Ray Humans Ion Channel Gating Kv1.2 Potassium Channel Membrane Potentials Potassium Channels, Voltage-Gated Protein Structure, Tertiary Protein Subunits Comment Journal Article Review

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Benoit Roux. 2006-11-22. Dissecting the coupling between the voltage sensor and pore domains.. https://doi.org/10.1016/j.neuron.2006.11.002

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