Modafinil and cocaine interactions.

Robert Malcolm; Karla Swayngim; Jennifer L Donovan; C Lindsay DeVane; Ahmed Elkashef; Nora Chiang; Roberta Khan; Jurij Mojsiak; Donald L Myrick; Sarra Hedden; Kristi Cochran; Robert F Woolson

doi:10.1080/00952990600920425

PubMed · 17127546

Modafinil and cocaine interactions.

Robert Malcolm·Karla Swayngim·Jennifer L Donovan·C Lindsay DeVane·Ahmed Elkashef·Nora Chiang·Roberta Khan·Jurij Mojsiak·Donald L Myrick·Sarra Hedden·Kristi Cochran·Robert F Woolson

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Abstract

This Phase I trial evaluated the interaction between modafinil steady-state and cocaine. Twelve non-treatment seeking, cocaine dependent volunteers received four sets of randomized blinded infusions of saline, 20 mg IV cocaine, and 40 mg IV cocaine. Modafinil was given open label at 0 mg, 400 mg, or 800 mg. Modafinil combined with IV cocaine did not result in any significant hemodynamic interactions. Modafinil significantly dampened scores on Visual Analog Scale measures as compared to baseline cocaine conditions. No significant alterations in labs occurred. Further outpatient trials of modafinil appear to be warranted.

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Benzhydryl Compounds Blood Pressure Cocaine Cocaine-Related Disorders Drug Interactions Humans Infusions, Intravenous Modafinil Neuroprotective Agents Safety Treatment Outcome Clinical Trial, Phase I Journal Article Research Support, N.I.H., Extramural

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Robert Malcolm, Karla Swayngim, Jennifer L Donovan, C Lindsay DeVane, Ahmed Elkashef, Nora Chiang, Roberta Khan, Jurij Mojsiak, Donald L Myrick, Sarra Hedden, Kristi Cochran, Robert F Woolson. 2006. Modafinil and cocaine interactions.. https://doi.org/10.1080/00952990600920425

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