Presentation of a functional pituitary adenoma as a significant decrease in prostate-specific antigen level in a patient followed for prostate cancer.

Aaron B Grotas; Harris M Nagler

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PubMed · 17187699

Presentation of a functional pituitary adenoma as a significant decrease in prostate-specific antigen level in a patient followed for prostate cancer.

Aaron B Grotas·Harris M Nagler

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Abstract

The stimulatory role of testosterone in the production and release of prostate-specific antigen (PSA) has been well characterized. Testosterone production by the testes is dependent on a functional hypothalamic-pituitary-gonadal axis. High prolactin levels have been shown to disrupt this axis, resulting in decreases in gonadotropins and testosterone levels. We report a patient with prostate cancer and elevated PSA levels followed with "watchful waiting" for several years who experienced a precipitous decrease in PSA level over a 3 month period. The patient was found to have an asymptomatic prolactin-secreting pituitary macroadenoma.

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Adenocarcinoma Aged, 80 and over Antineoplastic Agents Cabergoline Ergolines Humans Male Neoplasms, Second Primary Pituitary Neoplasms Prolactinoma Prostate-Specific Antigen Prostatic Neoplasms Case Reports Journal Article

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Aaron B Grotas, Harris M Nagler. 2006. Presentation of a functional pituitary adenoma as a significant decrease in prostate-specific antigen level in a patient followed for prostate cancer.. https://pubmed.ncbi.nlm.nih.gov/17187699/

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