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New gemacranolides from Eupatorium hualienense.

Ya-Ching Shen·Jiun-Yang Jang·Ashraf Taha Khalil·Lien Chai Chiang
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Abstract

Phytochemical investigation of Eupatorium hualienense (C. H. Ou, S. W. Chung, C. I. Peng) has resulted in the isolation of the new sesquiterpene lactones 1-5, named eupahualins A-E, along with the known heliangolide eupasimplicin B (6). The structures of the isolated compounds were established through detailed spectral analyses, especially by means of 2D-NMR techniques. Compounds 1-4 and 6 showed significant activities against cell lines of human chronic myelogenous leukemia (K562) and human bone cancer (U2OS).

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Antineoplastic AgentsCell Line, TumorEupatoriumHumansLactonesMolecular StructureSesquiterpenesStructure-Activity RelationshipJournal ArticleResearch Support, Non-U.S. Gov't

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Ya-Ching Shen, Jiun-Yang Jang, Ashraf Taha Khalil, Lien Chai Chiang. 2005. New gemacranolides from Eupatorium hualienense.. https://doi.org/10.1002/cbdv.200590007

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