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PubMed · 17205785

[Melatonin and bone status].

Zofia Ostrowska·Kinga Wołkowska-Pokrywa·Beata Kos-Kudła·Elzbieta Swietochowska·Bogdan Marek·Dariusz Kajdaniuk
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Abstract

This paper reviews the findings accumulated on the role of melatonin (MEL) on bone status and the role of RANKL/RANK/OPG system (receptor activator of nuclear factor-kappa B ligand/ receptor activator of nuclear factor-kappa B/osteoprotegerin) in this mechanism. Recent studies indicate that MEL may influence on the bone directly by acting osteoclasts and perhaps osteoblasts, and/or indirectly by down-regulating RANK-mediated osteoclast formation and activation. Induced by MEL, changes in the level of factors which play a role in the regulation of bone remodelling, may secondarily (directly and/or indirectly through RANKURANK/OPG system) influence on bone status.

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AnimalsBone DensityBone ResorptionBone and BonesFemaleHumansMelatoninOsteoblastsOsteoclastsOsteogenesisOsteoporosisPineal GlandRANK LigandReceptor Activator of Nuclear Factor-kappa BEnglish AbstractJournal ArticleReview

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Zofia Ostrowska, Kinga Wołkowska-Pokrywa, Beata Kos-Kudła, Elzbieta Swietochowska, Bogdan Marek, Dariusz Kajdaniuk. 2006. [Melatonin and bone status].. https://pubmed.ncbi.nlm.nih.gov/17205785/

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