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PubMed · 17207801

A randomized, prospective study comparing laser-assisted hatching and assisted hatching using acidified medium.

Susan E Lanzendorf·Valerie S Ratts·Kelle H Moley·Jerald S Goldstein·Michael H Dahan·Randall R Odem
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Abstract

OBJECTIVE: To compare the clinical outcomes of patients whose transferred embryos underwent either laser-assisted hatching or hatching with acidified medium. DESIGN: Randomized, prospective, double-blinded study. SETTING: University-based IVF center. PATIENT(S): Clinical outcomes following IVF were compared in 159 patient cycles who randomly had all transferred embryos undergo laser-assisted hatching (Laser; n = 57) or hatching with acidified medium (Acid; n = 54). Patients whose embryos had zonae thickness <13 mum were not hatched (Thin; n = 8) and patients with > or =4 embryos at the 7- to 8-cell stage or higher on Day 3 were transferred on Day 5 (Day 5; n = 40). MAIN OUTCOME MEASURE(S): Implantation rates, clinical pregnancy rates, ongoing pregnancy rates, multiple pregnancy rates. RESULT(S): No significant differences were noted in clinical, ongoing, or multiple pregnancy rates between the four groups. The implantation rate for Day 5 transfers was significantly greater than both the Laser and Acid treatment groups. CONCLUSION: The use of a 1.48-micron infrared diode laser beam provides a safe and rapid method for performing assisted hatching and did not have a negative impact on patient care when compared to outcomes achieved using acidified medium.

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AdultDouble-Blind MethodEmbryo TransferFemaleFertilization in VitroHumansLasersOvulation InductionPatient SelectionPregnancyPregnancy OutcomeProspective StudiesJournal ArticleRandomized Controlled Trial

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Susan E Lanzendorf, Valerie S Ratts, Kelle H Moley, Jerald S Goldstein, Michael H Dahan, Randall R Odem. 2007-01-04. A randomized, prospective study comparing laser-assisted hatching and assisted hatching using acidified medium.. https://doi.org/10.1016/j.fertnstert.2006.11.030

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