PubMed · 17208074
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
Polychronis Dilaveris, Georgios Giannopoulos, Maria Riga, Andreas Synetos, Christodoulos Stefanadis. 2007. Beat by beat variations.. https://doi.org/10.1016/j.amjmed.2006.10.009
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
The first total synthesis of the natural cytotoxic agent sporiolide A has been accomplished from D-glucal in 16 steps with 6.1% overall yield. Carbohydrates were applied as the chiral templates to manipulate the absolute configuration during the synthesis. Pyridinium chlorochromate (PCC)-promoted transformation of the cyclic enol-ether to lactone, followed by Yamaguchi esterification and intramolecular ring closure metathesis, greatly facilitates synthesis of the target compound.
Explore the source record for details and available documents.
Four derivatives of 2(II)-deoxycellobiose were synthesized from d-glucal and acceptor sugars (d-glucose, d-xylose, d-mannose, and 2-deoxy-d-arabino-hexose) using a cellobiose phosphorylase from Cellvibrio gilvus. The enzyme was found to be an effective catalyst to synthesize the beta-(1-->4) linkage of 2-deoxy-d-arabino-hexopyranoside. The acceptor specificity for the d-glucal reaction was identical to that for the alpha-d-glucose 1-phosphate reaction, but the activity of d-glucal was approximately 500 times less than that of alpha-d-glucose 1-phosphate, using 10mM substrates.