Septamycin, a polyether antibiotic. Taxonomy, fermentation, isolation and characterization.

C Keller-Juslén; H D King; Z L Kis; A von Wartburg

doi:10.7164/antibiotics.28.854

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Septamycin, a polyether antibiotic. Taxonomy, fermentation, isolation and characterization.

C Keller-Juslén·H D King·Z L Kis·A von Wartburg

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Abstract

Septamycin is a metal complexing polyether antibiotic produced by a strain of Streptomyces hygroscopicus NRRL 5678. The metabolite, a monocarboxylic acid, was isolated as the sodium salt C48H81NaO16. The crystal structure and absolute configuration were established by X-ray analysis of the p-bromophenacyl derivative. Septamycin has a thirty-carbon backbone and contains seven heterocyclic rings. Supported by direct comparison septamycin proved to be identical with antibiotic A28695 A isolated from Streptomyces albus NRRL 3883. The metabolite is active against gram-positive bacteria and Eimeria tenella (chicken coccidiosis).

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Animals Anti-Bacterial Agents Bacteria Chemical Phenomena Chemistry Chickens Coccidiosis Dogs Ethers Newcastle disease virus Poultry Diseases Rats Simplexvirus Streptomyces Journal Article

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C Keller-Juslén, H D King, Z L Kis, A von Wartburg. 1975. Septamycin, a polyether antibiotic. Taxonomy, fermentation, isolation and characterization.. https://doi.org/10.7164/antibiotics.28.854

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