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PubMed · 175725

Halothane action on lymphocytes does not involve cyclic AMP.

D L Bruce
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Abstract

Both theophylline and halothane inhibited transformation of human lymphocytes by phytohemagglutinin (PHA). Theophylline did not augment the inhibitory action of halothane and depressed PHA transformation of halothane-treated cells to the same extent as that of air-treated cells. Halothane- and air-treated lymphocytes, prior to PHA addition, had the same content of cyclic AMP. The addition of PHA to these cultures raised cyclic-AMP concentrations to the same extent in halothane- and air-treated lymphocytes. Halothane action on PHA-stimulated lymphocytes appears not to involve changes in cyclic nucleotide metabolism.

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Cells, CulturedCyclic AMPHalothaneHumansLectinsLymphocyte ActivationLymphocytesTheophyllineJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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D L Bruce. 1976. Halothane action on lymphocytes does not involve cyclic AMP.. https://doi.org/10.1097/00000542-197602000-00012

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