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PubMed · 1804848

Estimating viral concentrations from dilution counts: a reliable computation method programmed on a pocket calculator.

P Roussel·J Husson
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Abstract

A program for a Hewlett-Packard 41C calculator is described, applying the maximum likelihood method for the estimation of the density of a suspension of infective particles when counts are available for a number of independent dilutions of the original suspension. An unbiased estimate for the variance of the density, a suitable confidence interval and its corresponding confidence level are also given by the program. Moreover, after testing for the presence of overcrowding and/or clumping, the selection of suitable dilutions is fully automated so as to avoid recourse to statistical tables.

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P Roussel, J Husson. Estimating viral concentrations from dilution counts: a reliable computation method programmed on a pocket calculator.. https://doi.org/10.1016/0166-0934(91)90093-f

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