First-order and pseudo-first-order elimination kinetics.

G Schüürmann

doi:10.1016/0048-9697(91)90194-j

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First-order and pseudo-first-order elimination kinetics.

G Schüürmann

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Abstract

There is evidence that, for a number of chemicals, the elimination characteristics during bioconcentration do not follow monophasic first-order kinetics. In the first part of the present communication, a simple mathematical formula is presented that allows a clear-cut distinction between monophasic (pseudo-) and first-order and morephasic or higher-order elimination processes. The second part gives the mathematical description of a simple monophasic pseudo-first-order two-compartment model, which allows a quantitative kinetic analysis in the case of both initial compound and metabolite elimination.

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G Schüürmann. 1991. First-order and pseudo-first-order elimination kinetics.. https://doi.org/10.1016/0048-9697(91)90194-j

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