PubMed · 182423
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
W C Weese. 1976. Case report.. https://pubmed.ncbi.nlm.nih.gov/182423/
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
A 16-year-old Thoroughbred gelding was evaluated for respiratory disease and found to have a primary lung tumor on postmortem examination. A tentative antemortem diagnosis was made on the basis of results of radiography and cytologic examination of a needle aspirate guided by ultrasonography. A histologic diagnosis of bronchioalveolar adenocarcinoma was made. Thoracic neoplasia is rare in horses. The most frequently reported primary pulmonary tumor is the granular cell tumor.
A retroviral etiology has been proposed for ovine pulmonary carcinoma (OPC); however, the putative virus (OPCV) has yet to be cultured. A Western immunoblotting assay using a panel of retroviral antisera was developed to further define the structural proteins of the virus associated with OPC and to confirm their presence in tumor samples of affected sheep. The results confirmed that the main structural viral component, the capsid protein (CA), was present in tumor materials (lung fluids, lavages, and tumor homogenates) but not in similar samples from control subjects. A second viral protein was detected in the tumor samples by antisera to the nucleocapsid protein (NC) of type D retroviruses. Both components could be purified from the tumor material in a manner consistent with association in viral particles. The cross-reactivity of the OPC antigens to other type B and D retroviruses was assessed. These results suggest that OPC antigens are closely related to the structural proteins of several type D primate retroviruses.
Levamisole in combination with radiation and chemotherapeutic agents is being studied in clinical trials. The mechanism of interaction of levamisole with these modalities is unknown. In order to determine if there is direct interaction between radiation and levamisole, a series of colony-formation assays was performed with the use of two human tumor cell lines. Cells were exposed to 0-10 Gy of radiation, with or without the addition of 0-1000 microM levamisole. Exposure to levamisole alone had no effect on cell survival; however, the combination of continuous exposure to levamisole at concentrations approaching 1000 microM and radiation revealed a potentiation of radiation-induced cell killing.