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PubMed · 183579

Vitamin D endocrinology.

H F DeLuca
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Abstract

Current status of our understanding of the metabolism of vitamin D and its implications in metabolic bone disease is reviewed. The details of metabolism of vitamin D3 to 25-hydroxyvitamin D3 in the liver and its further conversion in the kidneys to either 1,25-dihydroxyvitamin D3 or 24,25-dihydroxyvitamin D3 are presented. The latter conversions are regulated by the vitamin D status, serum calcium through the parathyroid gland system, and serum inorganic phosphorus concentration. The 1,25-dihydroxyvitamin D3 can now be regarded as a calcium- and a phosphate-mobilizing hormone and must be considered as one of the most important serum calcium-regulating hormones. Disruption of the vitamin D metabolic sequence or the signal system for 1,25-dihydroxyvitamin D3 results in several bone and calcium metabolism disorders such as renal osteodystrophy, hypoparathyroidism, pseudohypoparathyroidism, and vitamin D-dependency rickets. The use of the synthetic analogs of 1,25-dihydroxyvitamin D3 as well as 1,25-dihydroxyvitamin D3 itself in the management of these disease states is discussed.

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AnimalsCalciumCholecalciferolChronic Kidney Disease-Mineral and Bone DisorderEndocrine GlandsErgocalciferolsHomeostasisHumansHyperparathyroidism, SecondaryIntestinal AbsorptionKidneyPhosphatesVitamin DJournal ArticleResearch Support, U.S. Gov't, P.H.S.Review

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H F DeLuca. 1976. Vitamin D endocrinology.. https://doi.org/10.7326/0003-4819-85-3-367

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