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PubMed · 1835930

Ipratropium bromide for symptomatic preterm infants.

B Yuksel·A Greenough
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Abstract

Twelve preterm infants, median gestational age 31.5 weeks, were entered into a randomised, placebo-controlled trial of bronchodilator therapy. Their postnatal age was a median of 17.5 months and all suffered from recurrent respiratory symptoms. The infants received either inhaled placebo or 40 micrograms of ipratropium bromide (active therapy) three times a day utilising a coffee cup as a spacer device. Each therapy was administered for 2 weeks. The symptom score during the active period was reduced by 59% compared to the placebo period (P less than 0.01) and this was associated with 38% improvement in lung function in the active period compared to a 20% change in functional residual capacity over the placebo period (P less than 0.01). We conclude inhaled ipratropium bromide appears to be an effective treatment for symptomatic infants at follow up.

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Birth WeightFemaleFunctional Residual CapacityGestational AgeHumansInfantInfant, NewbornInfant, PrematureIpratropiumMaleRespiratory Distress Syndrome, NewbornClinical TrialJournal ArticleRandomized Controlled TrialResearch Support, Non-U.S. Gov't

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B Yuksel, A Greenough. 1991. Ipratropium bromide for symptomatic preterm infants.. https://doi.org/10.1007/bf01955008

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