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Selenium in human mammary carcinogenesis: a case-referent study.

K Overvad·P Grøn·O Langhoff·U Tarp·A Foldspang·E B Thorling
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Abstract

In a case-referent study on the possible role of selenium in human mammary carcinogenesis, serum selenium was found to be 79 +/- 12 micrograms/l in 66 cases and 81 +/- 12 micrograms/l in 93 referents. An internal trend in serum selenium was observed among cases (TNM stage I 81 +/- 11 micrograms/l and TNM stage II 76 +/- 13 micrograms selenium/l), indicating disease-mediated changes. The evaluation of selenium as a risk indicator in human breast cancer was therefore restricted to TNM stage I patients (n = 36). Multiple logistic regression analyses including variables associated with selenium levels revealed no association between selenium levels and breast cancer risk.

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AdenocarcinomaAdultAge FactorsAgedBody WeightBreast NeoplasmsCase-Control StudiesFemaleHumansMenopauseMiddle AgedNeoplasm StagingRisk FactorsSeleniumSerum AlbuminSmokingJournal Article

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K Overvad, P Grøn, O Langhoff, U Tarp, A Foldspang, E B Thorling. 1991. Selenium in human mammary carcinogenesis: a case-referent study.. https://doi.org/10.1097/00008469-199110000-00005

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