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PubMed · 1892351

Analytical goals for interference.

X Fuentes-Arderiu·C G Fraser
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Abstract

Objective analytical goals for interference in clinical biochemical methods have not yet been advocated. We propose that, since total analytical error is ideally less than half the within-subject biological coefficient of variation (CVI), the maximum allowable systematic error produced by an interferent (I) is: I less than CVI-(1.96 CVA + SE), where CVA is the relevant experimental analytical imprecision and SE is the systematic error. Such a goal may be applicable also to non-specificity, matrix effects and carryover.

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Chemistry Techniques, AnalyticalChemistry, ClinicalData Interpretation, StatisticalFalse Negative ReactionsFalse Positive ReactionsSensitivity and SpecificityJournal Article

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X Fuentes-Arderiu, C G Fraser. 1991. Analytical goals for interference.. https://doi.org/10.1177/000456329102800414

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