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PubMed · 1906017

Ovulatory dysfunction during continuous administration of low-dose levonorgestrel by subdermal implants.

A Faundes·V Brache·A S Tejada·L Cochon·F Alvarez-Sanchez
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Abstract

OBJECTIVE: To study the endocrinologic profile of regularly menstruating users of levonorgestrel subdermal implants. DESIGN: Observational, prospective, case-controlled comparative study. SETTING: The Family Planning Clinic of PROFAMILIA, in Santo Domingo, Dominican Republic. PATIENTS, PARTICIPANTS: Thirty one regularly cycling Norplant users and 12 nonhormonal contraceptors who volunteered to participate. INTERVENTIONS: Norplant contraceptive implants were inserted in 31 subjects between 13 and 77 months before this study. MAIN OUTCOME MEASURES: Follicle-stimulating hormone, luteinizing hormone, estradiol (E2), and progesterone (P) were serially assayed for one menstrual cycle. RESULTS: Almost half of the cycles among Norplant users were anovulatory; all the rest (55%) had some form of dysfunction: diminished gonadotropin surge, luteal phase insufficiency (low P levels and shortened luteal phase), and E2 profiles different from normal controls. CONCLUSIONS: Anovulation is clearly one of the main mechanisms of action of Norplant, but even in presumptive ovulatory cycles, the dysfunctions described possibly contribute to the high contraceptive effectiveness of Norplant.

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AdultAnovulationCase-Control StudiesContraceptives, Oral, CombinedDrug ImplantsEstradiolFemaleFollicle Stimulating HormoneHumansLevonorgestrelLuteinizing HormoneNorgestrelOvulationProgesteroneProspective StudiesAmericasBiologyCaribbeanCase Control StudiesContraceptionContraceptive Agents, Female--administraction and dosageContraceptive Agents, Female--side effectsContraceptive Agents, Progestin--administraction and dosageContraceptive Agents, Progestin--side effectsContraceptive Agents--administraction and dosageContraceptive Agents--side effectsContraceptive Implants--administraction and dosageContraceptive Methods--administraction and dosageContraceptive Mode Of ActionDeveloping CountriesDominican RepublicEndocrine System--changesEstradiol--analysisEstrogensExaminations And DiagnosesFamily PlanningFollicle Stimulating Hormone--analysisGonadotropinsGonadotropins, PituitaryHormonesLaboratory Examinations And DiagnosesLatin AmericaLevonorgestrel--administraction and dosageLevonorgestrel--side effectsLuteinizing Hormone--analysisNorth AmericaPhysiologyProgestational HormonesProgesterone--analysisReproductionResearch MethodologyStudiesComparative StudyJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.

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A Faundes, V Brache, A S Tejada, L Cochon, F Alvarez-Sanchez. 1991. Ovulatory dysfunction during continuous administration of low-dose levonorgestrel by subdermal implants.. https://pubmed.ncbi.nlm.nih.gov/1906017/

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