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PubMed · 1908951

Bcl-2 maintains B cell memory.

G Nuñez·D Hockenbery·T J McDonnell·C M Sorensen·S J Korsmeyer
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Abstract

The number of lymphocytes in an animal is remarkably constant despite antigen-driven proliferation and a high rate of B-cell lymphopoiesis. This reflects the relatively brief lifespan of many newly generated B cells and argues for a well-regulated death mechanism. Even so, a secondary immune response can be generated years after a primary exposure to antigen. Antigen that might restimulate B cells persists for extended periods on follicular dendritic cells in the light zone of germinal centres. Antigen-binding B cells have also been found months after the end of obvious cell division. The precise signal that enables certain B cells to emerge as long-term surviving memory cells is unknown. Bcl-2, an inner mitochondrial membrane protein, blocks programmed cell death in B cells. We report here that this proto-oncogene maintains immune responsiveness. Transgenic mice overproducing Bcl-2 have a long-term persistence of immunoglobulin-secreting cells and an extended lifetime for memory B cells.

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AnimalsAntigensB-LymphocytesCell SurvivalFluorescein-5-isothiocyanateFluoresceinsFluorescent DyesHemocyaninsImmunizationImmunization, PassiveImmunoglobulin GImmunoglobulin MImmunologic MemoryKineticsMiceMice, TransgenicProto-Oncogene ProteinsProto-Oncogene Proteins c-bcl-2ThiocyanatesJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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G Nuñez, D Hockenbery, T J McDonnell, C M Sorensen, S J Korsmeyer. 1991-09-05. Bcl-2 maintains B cell memory.. https://doi.org/10.1038/353071a0

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