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PubMed · 1919592

Additional bioactive heptenes from Melodorum fruticosum.

J H Jung·C J Chang·D L Smith·J L McLaughlin·S Pummangura·C Chaichantipyuth·C Patarapanich
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Abstract

Four additional new bioactive heptenes, melodorinol [2], homomelodienone [4], 7-hydroxy-6-hydromelodienone [5], and homoisomelodienone [7] have been isolated from Melodorum fruticosum. These compounds were slightly to significantly cytotoxic to human tumor cell lines. Their structures have been determined by comparison of their 1H-nmr, 13C-nmr, and mass spectral data with those of prototype compounds (acetylmelodorinol [1], melodienone 3, and isomelodienone [6]).

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AlkenesAnimalsAntineoplastic Agents, PhytogenicArtemiaDrug Screening Assays, AntitumorHumansMagnetic Resonance SpectroscopyMolecular StructurePlantsTumor Cells, CulturedJournal ArticleResearch Support, U.S. Gov't, P.H.S.

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J H Jung, C J Chang, D L Smith, J L McLaughlin, S Pummangura, C Chaichantipyuth, C Patarapanich. Additional bioactive heptenes from Melodorum fruticosum.. https://doi.org/10.1021/np50074a023

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