S-erythropoietin levels decrease in patients with chronic hypoxia starting domiciliary oxygen therapy.

K Ström; H Odeberg; A C Andersson; J Boe; J Singer; G Svensson

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PubMed · 1955004

S-erythropoietin levels decrease in patients with chronic hypoxia starting domiciliary oxygen therapy.

K Ström·H Odeberg·A C Andersson·J Boe·J Singer·G Svensson

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Abstract

Consecutive determinations of erythropoietin in serum (s-Epo) were made in ten patients with chronic hypoxia starting domiciliary long-term oxygen therapy (LTO). After 24 h of supplementary oxygen treatment there was a fall in the median s-Epo level from 11.3 to 4.4 IU.l-1 (p less than 0.01). The initial decrease in s-Epo in conjunction with oxygen treatment was not sustained after one and three months of LTO. S-Epo levels above the reference range (3.3-13.5 IU.l-1) were found in three patients before and during LTO and in another two patients during LTO. Markedly elevated s-Epo levels were found in two patients with hypoxia and hypercapnia at the time of blood sampling. A significant negative relationship was found between the arterial oxygen tension and the log value for the s-Epo level (r = 0.40, p less than 0.005). The s-Epo levels were found to be normal in half of the measurements in patients using oxygen less than 15 h daily, a fact that indicates that s-Epo measurements are probably not suitable as indicators of compliance with LTO.

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Aged Aged, 80 and over Chronic Disease Erythropoietin Home Care Services Humans Hypoxia Long-Term Care Male Middle Aged Oxygen Inhalation Therapy Patient Compliance Journal Article Research Support, Non-U.S. Gov't

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K Ström, H Odeberg, A C Andersson, J Boe, J Singer, G Svensson. 1991. S-erythropoietin levels decrease in patients with chronic hypoxia starting domiciliary oxygen therapy.. https://pubmed.ncbi.nlm.nih.gov/1955004/

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