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Minisatellite repeat coding as a digital approach to DNA typing.

A J Jeffreys·A MacLeod·K Tamaki·D L Neil·D G Monckton
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Abstract

Most DNA typing systems used in forensic and legal medicine assay allelic length variation at tandem repetitive DNA regions such as minisatellites. A simple alternative approach that displays patterns of variant repeat units along minisatellite alleles is described here. This produces DNA profiles as extraordinarily variable digital sequences appropriate for forensic investigations, including computer databasing, and for analysing allele diversity and the role of recombination in minisatellite instability.

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Base SequenceChromosome MappingDNA FingerprintingDNA ProbesDNA, SatelliteFemaleGenetic VariationHaplotypesHeterozygoteHumansMaleMolecular Sequence DataMutationPolymerase Chain ReactionRepetitive Sequences, Nucleic AcidSequence Homology, Nucleic AcidJournal ArticleResearch Support, Non-U.S. Gov't

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A J Jeffreys, A MacLeod, K Tamaki, D L Neil, D G Monckton. 1991-11-21. Minisatellite repeat coding as a digital approach to DNA typing.. https://doi.org/10.1038/354204a0

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