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Imipramine and desipramine decrease the GABA-stimulated chloride uptake, and antigabaergic agents enhance their action in the forced swimming test in rats.

A Fernández-Teruel·R M Escorihuela·F Boix·B Longoni·M G Corda·A Tobeña
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Abstract

The present study reports that long-term (18 days) administration of imipramine (IMI, 20 mg/kg) or desipramine (DMI, 15 mg/kg) produced a significant decrease in the GABA-stimulated 36Cl- uptake into membrane vesicles from the cerebral cortex of rats (experiment 1). Experiments 2A, B show that anti-immobility effects of DMI and IMI (subacute treatment) in the forced swimming test are enhanced when a single subconvulsant injection of picrotoxin or pentylenetetrazol is administered to the animals concurrently to the last antidepressant injection. These results are discussed in relation with a current GABAergic hypothesis of depression and antidepressant drug action.

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AnimalsCerebral CortexChloridesChlorineDepressionDesipramineGABA AntagonistsImipramineMalePentylenetetrazolePicrotoxinRadioisotopesRatsRats, Inbred StrainsReceptors, GABA-ASwimminggamma-Aminobutyric AcidJournal ArticleResearch Support, Non-U.S. Gov't

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A Fernández-Teruel, R M Escorihuela, F Boix, B Longoni, M G Corda, A Tobeña. Imipramine and desipramine decrease the GABA-stimulated chloride uptake, and antigabaergic agents enhance their action in the forced swimming test in rats.. https://doi.org/10.1159/000119442

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