Developments in pertussis immunisation in Japan.

M Kimura; H Kuno-Sakai

doi:10.1016/0140-6736(90)91530-n

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Developments in pertussis immunisation in Japan.

M Kimura·H Kuno-Sakai

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Abstract

In Japan acellular pertussis vaccine has totally replaced whole-cell vaccine since 1981. The vaccine is given in combination with diphtheria and tetanus toxoids to children aged 24-48 months; three doses are given with intervals of 3-8 weeks and the fourth dose (booster) is given 12-18 months after the third. There has been a steady decline in cases of pertussis and deaths from the disease since 1979. Comparison of the rates of adverse reactions to whole-cell vaccine in 1973-74 and to acellular vaccine in 1979-80 showed lower rates of fever and of local reactions with the acellular vaccine.

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Child Child, Preschool Diphtheria-Tetanus-Pertussis Vaccine Drug Evaluation Health Policy Humans Immunization Schedule Immunization, Passive Infant Infant, Newborn Japan Pertussis Vaccine Pilot Projects Time Factors Vaccination Whooping Cough Comparative Study Journal Article

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M Kimura, H Kuno-Sakai. 1990-07-07. Developments in pertussis immunisation in Japan.. https://doi.org/10.1016/0140-6736(90)91530-n

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