PubMed · 1976182
The source did not provide an abstract. Follow the original record for more information.
Explore connections, maps & timelines
M Duran, P Rovers, P K de Bree, C H Schreuder, H Beukenhorst, L Dorland, R Berger. 1990-09-29. Dihydropyrimidinuria.. https://doi.org/10.1016/0140-6736(90)93288-z
Cite the original work for its findings. Save a collection to share your selection of sources.
KEEP EXPLORING
An extensive study on the application of the "zero-crossing" technique for the analysis of a binary mixture of the photosensitive drug lacidipine and its corresponding by-product by derivative spectrophotometry is described. The technique has been compared to either conventional and recently developed UV spectrophotometric procedures, including chemometric methods. The prediction ability of the different analytical techniques has been checked by using the first-order derivative spectra of drug and photoproduct in binary mixtures. Relative advantages and drawbacks have been discussed. The zero-crossing technique suffers from several limitations, mostly ascribed to the selection of suitable signals along slopes of the spectral curve, giving rise to low accurate and precise results. The mean recovery from the zero-crossing analysis was calculated to lie in the 95.1-98.4% range for lacidipine, and 91.2-118.9% for the photoproduct. Chemometric methods showed a greater prediction ability with a 101.4-103.0% and 96.3-98.4% recovery for drug and degradation product, respectively.
Photochemical behavior of some 1,4-dihydropyridines has been investigated in the solid state. Whereas upon irradiation of 1,4-dihydropyridines in solution phase, their photo-oxidation and formation of pyridine derivatives have been observed, irradiation of these compounds in the solid state decreases their light sensitivity. In many cases photo-oxidation has been observed only in very low yields.
Explore the source record for details and available documents.