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PubMed · 2010951

Interaction between adenosine and beta-adrenoceptors.

D Saito·T Mima·S Uchida·N Obayashi·M Marutani·N Mukohara·S Kusachi·T Tsuji·S Haraoka
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Abstract

Interaction between adenosine and isoproterenol (ISP) on myocardial inotropic action was studied in open-chest dog hearts. The local myocardial force and the left ventricular (LV) dP/dt were measured as indices of myocardial contractility. Isoproterenol [ISP, 9.47 microM (2 micrograms/ml)] was infused into the left circumflex coronary artery at rates of 0.05 ml/min (low dose ISP) or 0.2 ml/min (high dose ISP). Two mM adenosine or 0.5 mM N6-phenylisopropyl-adenosine (PIA) were infused into the coronary artery at rates of 0.2 (4 x 10(-7) mol/min), 0.5 (1 x 10(-6) mol/min) and 10 ml/min (2 x 10(-5) mol/min) in the presence of either a low or a high dose of ISP. Adenosine infusion at a rate of 0.2 ml/min did not modify myocardial contractility in the presence of the both doses of ISP. The larger doses of adenosine, 0.5 ml/min and 10 ml/min, decreased myocardial-developed tension and LVmax dP/dt dose-dependently. However, the dose of adenosine which affected myocardial contractility was inphysiologically high in comparison with the concentration in the ischemic myocardium. PIA, a potent agonist of adenosine A1-receptor, attenuated an increase in myocardial contractility in a dose-dependent manner which was caused by intracoronary ISP infusion. This indicates that A1-adenosine receptors exist, but a functional adenosine-catecholamine antagonism does not play a significant role in the canine left ventricle.

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AdenosineAnimalsBlood PressureCoronary CirculationDogsDose-Response Relationship, DrugDrug InteractionsHeart RateIsoproterenolMyocardial ContractionStimulation, ChemicalVentricular Function, LeftJournal Article

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BibTeXRIS

D Saito, T Mima, S Uchida, N Obayashi, M Marutani, N Mukohara, S Kusachi, T Tsuji, S Haraoka. 1991. Interaction between adenosine and beta-adrenoceptors.. https://doi.org/10.1253/jcj.55.81

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