Early bone changes in experimental osteoarthritis using microscopic computed tomography.

D K Dedrick; R Goulet; L Huston; S A Goldstein; G G Bole

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PubMed · 2027128

Early bone changes in experimental osteoarthritis using microscopic computed tomography.

D K Dedrick·R Goulet·L Huston·S A Goldstein·G G Bole

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Abstract

Alterations in trabecular subchondral bone have been measured using a microscopic computed tomography scanner in the guinea pig hind-limb myectomy model of osteoarthritis. These bone changes can be found as early as histologic changes in cartilage. To evaluate the influence of the myectomy on the animals, a gait study was performed. This data reveals an alteration in acceleration at the foot-flat phase of gait in the operated limb only, providing early quantification of the interaction between mechanics and biology.

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Animals Biomechanical Phenomena Bone and Bones Cartilage Disease Models, Animal Gait Guinea Pigs Osteoarthritis Tomography, X-Ray Computed Journal Article Research Support, U.S. Gov't, P.H.S.

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D K Dedrick, R Goulet, L Huston, S A Goldstein, G G Bole. 1991. Early bone changes in experimental osteoarthritis using microscopic computed tomography.. https://pubmed.ncbi.nlm.nih.gov/2027128/

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