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PubMed · 2032810

Halogenated inhalation anesthetic agents decrease transepithelial electrical measurements across the isolated iris-ciliary body.

L Q Tang·T Krupin·M Milner·D Woods·K Miller·D A Carré·M M Civan
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Abstract

Transmembrane electrical measurements were performed on the isolated rabbit iris-ciliary body (I-CB) to study the direct effects of halogenated inhalation anesthetic agents on the ciliary epithelium. Addition of either halothane, enflurane, or isoflurane to the control 95% O2:5% CO2 gas mixture resulted in a dose-dependent decrease in the short-circuit current (SCC) and potential difference (PD). This response was reversible after the anesthetic gas was discontinued. Pretreatment with either alpha-adrenergic or beta-adrenergic antagonists (phentolamine or timolol) had no effect on the halothane-induced decrease in SCC. Delivery of the analgestic gas N2O did not alter baseline electrical measurements across the isolated I-CB.

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Analysis of VarianceAnesthesia, InhalationAnestheticsAnimalsCiliary BodyEnfluraneHalothaneIrisIsofluraneMaleMembrane PotentialsRabbitsJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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L Q Tang, T Krupin, M Milner, D Woods, K Miller, D A Carré, M M Civan. 1991. Halogenated inhalation anesthetic agents decrease transepithelial electrical measurements across the isolated iris-ciliary body.. https://pubmed.ncbi.nlm.nih.gov/2032810/

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