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PubMed · 2065793

Progesterone administration by nasal spray.

E Cicinelli·G Ragno·I Cagnazzo·F Fanelli·C Vetuschi·S Schonauer
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Abstract

The bioavailability and the clinical usefulness of the P administered by nasal spray were investigated. Ten healthy menopausal women received an IN spray administration (4 doses of an oleic P solution 20 mg/mL, corresponding to nearly 11.2 mg of P) and the circulating P levels were calculated. Sixty minutes after administration, the maximum concentration (CMax, 3.75 +/- 0.214 ng/mL) was reached. High P levels (greater than 2 ng/mL) lasted until 360 minutes, and the AUC 0 to 720 was 1,481.6 +/- 343 ng.h/mL. Progesterone administration by spray formulation has proven to be effective in reaching therapeutic levels and to be acceptable to patients and, probably, clinically safe.

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AbsorptionAdministration, IntranasalBiological AvailabilityFemaleHumansKineticsMiddle AgedProgesteroneAmericasBiologyClinical ResearchContraceptionContraception ResearchDeveloped CountriesEndocrine SystemFamily PlanningHormonesNorth AmericaNorthern AmericaPhysiologyProgestational HormonesProgesterone--administraction and dosageProgesterone--pharmacodynamicsResearch MethodologyUnited StatesJournal Article

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E Cicinelli, G Ragno, I Cagnazzo, F Fanelli, C Vetuschi, S Schonauer. 1991. Progesterone administration by nasal spray.. https://doi.org/10.1016/s0015-0282(16)54433-1

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