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PubMed · 2104579

Relapsing post-hepatitis aplastic anemia. Immunosuppressive therapy.

K Shannon·W Koehne·M B Heyman·M A Koerper
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Abstract

A 20-month-old Hispanic male developed severe aplastic anemia after an episode of non-A, non-B hepatitis. Prompt and complete recovery of all hematopoietic cell lines occurred after treatment with antithymocyte globulin (ATG) and high-dose corticosteroids. Severe aplasia recurred two months later coincident with a mild upper respiratory infection. A second course of immunosuppressive therapy was followed by complete, sustained improvement. The authors' experience provides clinical evidence indicating that immunologic mechanisms are important in the treatment of severe post-hepatitis aplastic anemia. Children in whom aplastic anemia recurs after immunosuppressive treatment may respond to a second course of therapy.

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Adrenal Cortex HormonesAnemia, AplasticAntilymphocyte SerumHepatitis CHepatitis, Viral, HumanHumansInfantMaleRecurrenceRespiratory Tract InfectionsCase ReportsJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.

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K Shannon, W Koehne, M B Heyman, M A Koerper. 1990. Relapsing post-hepatitis aplastic anemia. Immunosuppressive therapy.. https://doi.org/10.1177/000992289002900103

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