Maternal effect on micronucleus induction in MS/Ae mice.

S Sutou; S Sato

doi:10.1002/em.2850150302

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Maternal effect on micronucleus induction in MS/Ae mice.

S Sutou·S Sato

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Abstract

MS/Ae mice, which are mutagen-sensitive in both the dominant lethal test and micronucleus test, and CD-1 mice, which are the parental strain of MS/Ae, were mated in all four possible combinations. Both male and female offspring were subjected to the micronucleus test using mitomycin C (MMC), colchicine (Col), and 6-mercaptopurine (6-MP). Col showed equivocal results. However, MMC and 6-MP showed differential responses in that both male and female offspring from CD-1 dams had lower incidences of micronucleated polychromatic erythrocytes than those from MS/Ae dams regardless of sire strain. In addition, body weights of offspring from MS/Ae dams were lower than those from CD-1 dams regardless of sire strain. Numbers of offspring from MS/Ae dams tended to be smaller than those from CD dams. These results suggest that the traits of MS/Ae mice are associated more with maternal factors than with paternal ones.

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Animals Animals, Newborn Cell Differentiation Colchicine Extrachromosomal Inheritance Female Litter Size Male Mercaptopurine Mice Mice, Inbred Strains Micronucleus Tests Mitomycin Mitomycins Pregnancy Journal Article

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S Sutou, S Sato. 1990. Maternal effect on micronucleus induction in MS/Ae mice.. https://doi.org/10.1002/em.2850150302

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