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PubMed · 2186775

Dose-response relationships for topically applied antigens.

H C Eun·R Marks
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Abstract

Patch-test responses to serially diluted nickel sulphate and potassium dichromate solutions in patients with nickel and chrome sensitivity were assessed by pulsed A-scan ultrasound to determine skin thickness and laser-Doppler flowmeter techniques to evaluate blood flow, as well as clinical scoring. There was a relationship between the dose of antigen and the test responses as measured by ultrasound and laser-Doppler flowmeter techniques in both nickel and chrome sensitive patients. Our data suggest that both techniques may be useful in the detection of allergic contact dermatitis in which there is a doubtful patch-test reaction as well as in experimental sensitization studies.

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ChromiumDermatitis, ContactDose-Response Relationship, DrugHumansLasersNickelPatch TestsUltrasonographyJournal Article

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BibTeXRIS

H C Eun, R Marks. 1990. Dose-response relationships for topically applied antigens.. https://doi.org/10.1111/j.1365-2133.1990.tb14726.x

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