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PubMed · 2195894

Simultaneous bilateral diffuse melanocytic uveal hyperplasia.

J M Rohrbach·W Roggendorf·S Thanos·K P Steuhl·H J Thiel
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Abstract

A 52-year-old woman noted loss of vision in August 1984. Clinical examination disclosed iris cysts and ciliary body cysts, macular edema, and uveal nevi. Cataract extraction and pressure-lowering operations were required in both eyes because of a tumor-induced angle-closure glaucoma. Vision, however, progressively decreased to light perception in each eye. Both eyes were finally enucleated because a malignant melanoma could not be ruled out, though iris tissue obtained in 1985 suggested a nevuslike process. Histologic study indicated a bilateral uveal hyperplasia. Results of light and electron microscopy, immunologic studies, and suspension cell culture suggested that the uveal hyperplasia was more likely a melanoma of low malignancy than a nevuslike process. We could not detect an extraocular primary tumor and assumed that this condition constituted an oncogenic syndrome.

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Diagnosis, DifferentialElectroretinographyEyeFemaleHumansHyperplasiaImmunologic TechniquesMelanocytesMelanomaMicroscopy, ElectronMiddle AgedNevusUveaUveal NeoplasmsCase ReportsJournal ArticleResearch Support, Non-U.S. Gov'tReview

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J M Rohrbach, W Roggendorf, S Thanos, K P Steuhl, H J Thiel. 1990-07-15. Simultaneous bilateral diffuse melanocytic uveal hyperplasia.. https://doi.org/10.1016/s0002-9394(14)76937-5

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