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Rat liver model for testing intraoperative echo contrast sonography.

A el Mouaaouy·H D Becker·R Schlief·C Kuhlo·C Portas
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Abstract

The present animal experimental study showed that intraoperative hepatic ultrasonography using an echo contrast medium can visualize small hepatomas (with a diameter of between 3 and 15 mm) induced in the rat liver, although they were not recognizable with plain ultrasonography. A homogeneous increase in the echogenicity of the liver tissue was achieved by using an echo contrast medium (Echovist) based on galactose microparticles. Self-made bubble preparations such as those used in echocardiography were far less effective. When the dosage was optimal (0.01-0.003 ml/g liver weight with concentrations of 200 and 300 mg/ml Echovist), homogeneous contrast enhancement of the liver was achieved for at least 10 min after a single bolus injection via all routes of contrast administration (hepatic artery, portal vein, bile duct). As a result, hepatomas appeared as hypodense formations (portal vein and bile duct) or as hyperdense zones (hepatic artery).

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AnimalsContrast MediaFemaleIntraoperative PeriodLiver Neoplasms, ExperimentalPolysaccharidesRatsRats, Inbred StrainsUltrasonographyJournal Article

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A el Mouaaouy, H D Becker, R Schlief, C Kuhlo, C Portas. 1990. Rat liver model for testing intraoperative echo contrast sonography.. https://doi.org/10.1007/bf00591273

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