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PubMed · 2229575

Grading liposarcomas with PET using [18F]FDG.

L P Adler·H F Blair·R P Williams·M N Pathria·J T Makley·M J Joyce·N al-Kaisi·F Miraldi
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Abstract

Five patients with liposarcomas of the thigh were studied using positron emission tomography (PET) with [18F]2-deoxy-2-fluoroglucose (FDG). There were three low-grade tumors (all National Cancer Institute Grade 1 myxoid liposarcomas) and two high-grade tumors (both pleomorphic liposarcomas, Grades 2 and 3). The low-grade liposarcomas were easily identified with an average dose uptake ratio (DUR) of 1.38 +/- 0.045 (mean +/- SD). The high-grade lesions were more avid for FDG with a mean DUR of 2.45 +/- 0.24. There was a significant difference (p = 0.004) in the DUR for the two groups and the histological grade of malignancy was highly correlated with the DUR for FDG (Rho = 0.89). These findings suggest that FDG-PET may be useful for distinguishing between low-grade and high-grade liposarcomas.

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DeoxyglucoseFluorodeoxyglucose F18HumansLiposarcomaSoft Tissue NeoplasmsThighTomography, Emission-ComputedJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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L P Adler, H F Blair, R P Williams, M N Pathria, J T Makley, M J Joyce, N al-Kaisi, F Miraldi. Grading liposarcomas with PET using [18F]FDG.. https://doi.org/10.1097/00004728-199011000-00017

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