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Loracarbef concentrations in middle ear fluid.

H Kusmiesz·S Shelton·O Brown·S Manning·J D Nelson
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Abstract

Loracarbef concentrations in plasma and middle ear fluid (MEF) were measured in specimens obtained approximately 2 h after doses of 7.5 or 15 mg/kg. The mean +/- standard deviation concentrations in MEF were 2.0 +/- 2.6 mg/liter (48% of the concentration in plasma) after the smaller dose and 3.9 +/- 2.6 mg/liter (42% of the concentration in plasma) after the larger dose. With the larger dose, the concentrations in MEF were greater than the MIC for 90% of strains of the usual pathogens of acute otitis media tested in 16 of 17 specimens.

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Body FluidsCephalosporinsChildChild, PreschoolEar, MiddleFemaleHumansInfantMaleOtitis MediaTympanoplastyJournal ArticleResearch Support, Non-U.S. Gov't

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H Kusmiesz, S Shelton, O Brown, S Manning, J D Nelson. 1990. Loracarbef concentrations in middle ear fluid.. https://doi.org/10.1128/aac.34.10.2030

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