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Delayed auditory brainstem response in thiamin-deficient rats.

Y Shigematsu·A Nakai·M Kuriyama·Y Kikawa·I Konishi·M Sudo·Y Itokawa
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Abstract

We recorded the auditory brainstem responses of rats fed a thiamin-deficient diet. The interpeak latencies between waves I and III, as well as those between waves I and IV, were significantly prolonged from day 24, while the latency of wave I was prolonged on day 26 of the thiamin-deficient diet. These delayed responses were corrected in 2 to 4 days after the initiation of daily intraperitoneal thiamin injections from day 32. The rats that were fed the thiamin-deficient diet, and then sacrificed on day 32, showed a decrease of total thiamin levels in the brain (26% of the level in control rat brains). Based on these results, we emphasize the value of the auditory brainstem response to detect thiamin deficiency.

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AnimalsBrainDietEvoked Potentials, Auditory, Brain StemLiverMaleRatsRats, Inbred StrainsThiamineThiamine DeficiencyJournal Article

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BibTeXRIS

Y Shigematsu, A Nakai, M Kuriyama, Y Kikawa, I Konishi, M Sudo, Y Itokawa. 1990. Delayed auditory brainstem response in thiamin-deficient rats.. https://doi.org/10.3177/jnsv.36.209

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