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PubMed · 2329812

Rat toxicity studies with beta-sitosterol.

T Malini·G Vanithakumari
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Abstract

Chronic administration of beta-sitosterol subcutaneously to rats for 60 days was well tolerated and there was no clear cut evidence of any gross or microscopic lesions either in the liver or kidney. Liver and kidney function tests were assessed by determining the blood/serum parameters like haemoglobin, blood glucose, serum protein, serum bilirubin, serum cholesterol, serum GPT and serum GOT. All the parameters were in the normal range except serum protein and serum cholesterol. Serum cholesterol was the only variable which depleted markedly in both sexes in a dose-dependent manner suggesting intrinsic hypocholesterolemic effect of the sterol.

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Alanine TransaminaseAnimalsAspartate AminotransferasesBilirubinBlood GlucoseBody WeightCholesterolDose-Response Relationship, DrugDrug Administration ScheduleFemaleHemoglobinsKidneyLiverMaleOrgan SizeRatsRats, Inbred StrainsSex CharacteristicsSitosterolsJournal ArticleResearch Support, Non-U.S. Gov't

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T Malini, G Vanithakumari. 1990. Rat toxicity studies with beta-sitosterol.. https://doi.org/10.1016/0378-8741(90)90032-o

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