PubMed · 2341908
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P Shaffer. 1990. Pitfalls in calculating filling and ejection parameters.. https://pubmed.ncbi.nlm.nih.gov/2341908/
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List-mode processing of gated cardiac blood pool data has be shown to been more accurate than standard frame-mode processing, but it has not gained widespread clinical use because of the difficulties associated with post-processing of the acquired data. We therefore investigated the possibility of performing the list-mode processing concurrently with the acquisition of the data, i.e. real-time list-mode processing. A programme for simultaneous acquisition and processing of gated cardiac images was written in assembly code and implemented on a personal computer. The programme was tested in phantom studies, then used in 200 consecutive patient examinations. Data could be concurrently acquired from the gamma-camera and processed with forward-backward framing at a great enough speed so that no loss of information occurred at up to 40,000 counts per second, a value exceeding typical count rates observed in clinical practice. The ease-of-use and the clinical benefits of real-time list-mode processing suggest that it may become a standard method for gated examinations of the left ventricle in the near future.
Receiver operating characteristic (ROC) analysis demonstrated that regional variations of sensitivity exist in the detection of wall motion abnormality in cardiac blood pool imaging studies. The observer response is significantly better in the apex than either the septum or posterolateral wall segments. The observer errors tend to be false-negative in the posterolateral wall segment and false-positive in the other two segments. Image presentation can make a significant difference to the overall sensitivity, and the monochrome cine-sequence performed best in this study.
Utilizing simplifying assumptions and a formula for ventricular radioactivity versus time, a method is presented for the estimation of systolic ventricular work. This value in MKS units is calculated from data available from the radionuclide blood pool ventriculogram.