Postmortem changes in brain catecholamine enzymes.

I B Black; S C Geen

doi:10.1001/archneur.1975.00490430069012

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Postmortem changes in brain catecholamine enzymes.

I B Black·S C Geen

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Abstract

Postmortem changes in the activities of tyrosine hydroxylase, dopa decarboxylase, and dopamine-beta-hydroxylase were examined in various areas of rat brain. Tyrosine hydroxylase activity decreased in an exponential fashion with a half-time of two to four hours in caudate-putamen, substantia nigra, and locus ceruleus. Dopa decarboxylase activity remained within 20% of control values at five hours in these areas, but then decreased precipitously. Dopamine-beta-hydroxylase activity remained within 20% of control for at least 20 hours after death.

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Animals Brain Caudate Nucleus Cerebral Ventricles Dopa Decarboxylase Dopamine beta-Hydroxylase Female Male Postmortem Changes Putamen Rats Substantia Nigra Time Factors Tyrosine 3-Monooxygenase Journal Article Research Support, U.S. Gov't, P.H.S.

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I B Black, S C Geen. 1975. Postmortem changes in brain catecholamine enzymes.. https://doi.org/10.1001/archneur.1975.00490430069012

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