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Ischemic flow threshold for striatal dopamine release in rats.

H Yao·H Ooboshi·S Sadoshima·K Takano·S Ibayashi·M Fujishima
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Abstract

To determine the level of cerebral blood flow reduction which causes striatal dopamine release, extracellular dopamine and cerebral blood flow was simultaneously determined using in vivo brain dialysis and a hydrogen clearance method, respectively, in the striatum of spontaneously hypertensive rats before and during experimental cerebral ischemia. The ischemic flow threshold for neurotransmitter dopamine release was found to be 20% of the resting value or 8-10 ml/100g/min of cerebral blood flow, being similar to those for energy and membrane failures.

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AnimalsBlood Flow VelocityCerebrovascular CirculationCorpus StriatumDopamineHypertensionIschemic Attack, TransientMaleRatsRats, Inbred SHRJournal ArticleResearch Support, Non-U.S. Gov't

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H Yao, H Ooboshi, S Sadoshima, K Takano, S Ibayashi, M Fujishima. 1990. Ischemic flow threshold for striatal dopamine release in rats.. https://doi.org/10.1007/bf00966215

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