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Patch-clamp technique in renal physiology.

L G Palmer
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Abstract

The patch-clamp technique of Neher and Sakmann and their colleagues has been widely used over the last 5 years to investigate ion channels in excitable tissues. More recently, it has become useful as a tool to study channels involved in transepithelial ion transport. In this review, I briefly cover the basic concepts behind the patch-clamp technique and the kinds of information that can be obtained with it. I then summarize the applications of the technique to renal tissues and describe some of the channel types that have been observed to date in epithelia.

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AnimalsCell MembraneElectric ConductivityEpitheliumEvaluation Studies as TopicIon ChannelsKidneyPhysiologyTissue DistributionJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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L G Palmer. 1986. Patch-clamp technique in renal physiology.. https://doi.org/10.1152/ajprenal.1986.250.3.f379

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